New studies suggest that NKG7 is essential for NK and CD8+ T cell cytotoxic degranulation and CD4+ T cell activation and proinflammatory responses. While the mechanism is yet to be determined, the functional relevance is exciting and opens the possibility of a new target for cellular immunotherapies.
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Malarkannan, S. NKG7 makes a better killer. Nat Immunol 21, 1139–1140 (2020). https://doi.org/10.1038/s41590-020-0767-5
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DOI: https://doi.org/10.1038/s41590-020-0767-5