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Jack of all trades inhibits inflammation (in sober people)

Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

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Fig. 1: Mechanism of GSDMD inhibition.


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F.I.S. is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the Emmy Noether Programme (SCHM 3336-1-1), SPP1923, SFB1403, TRR237 and Germany’s Excellence Strategy – EXC2151 – 390873048, as well as by the Klaus Tschira Boost Fund. E.L. is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through SPP1923, SFB1403, TRR237 and Germany’s Excellence Strategy – EXC2151 – 390873048.

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Correspondence to Florian I. Schmidt.

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Competing interests

E.L. is a cofounder of IFM Therapeutics. F.I.S. is a scientific consultant of IFM Therapeutics.

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Schmidt, F.I., Latz, E. Jack of all trades inhibits inflammation (in sober people). Nat Immunol 21, 718–719 (2020).

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