Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

PYROPTOSIS

Jack of all trades inhibits inflammation (in sober people)

Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Mechanism of GSDMD inhibition.

References

  1. 1.

    Hu, J. J. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0669-6 (2020).

  2. 2.

    Kayagaki, N. et al. Nature 526, 666–671 (2015).

    CAS  Article  Google Scholar 

  3. 3.

    Shi, J. et al. Nature 526, 660–665 (2015).

    CAS  Article  Google Scholar 

  4. 4.

    Broz, P., Pelegrín, P. & Shao, F. Nat. Rev. Immunol. 20, 143–157 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Zhou, Z. et al. Science https://doi.org/10.1126/science.aaz7548 (2020).

  6. 6.

    Ridker, P. M. Circ. Res. 124, 437–450 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Brydges, S. D. et al. J. Clin. Invest. 123, 4695–4705 (2013).

    CAS  Article  Google Scholar 

  8. 8.

    Sollberger, G. et al. Sci. Immunol. 3, eaar6689 (2018).

    Article  Google Scholar 

  9. 9.

    Ruan, J., Xia, S., Liu, X., Lieberman, J. & Wu, H. Nature 557, 62–67 (2018).

    CAS  Article  Google Scholar 

  10. 10.

    Liu, Z. et al. Immunity 51, 43–49.e4 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Mulvihill, E. et al. EMBO J. 37, e98321 (2018).

    Article  Google Scholar 

  12. 12.

    Skrott, Z. et al. Nature 552, 194–199 (2017).

    CAS  Article  Google Scholar 

  13. 13.

    Rathkey, J. K. et al. Sci. Immunol. 3, eaat2738 (2018).

    Article  Google Scholar 

  14. 14.

    Liu, X. et al. Nature 535, 153–158 (2016).

    CAS  Article  Google Scholar 

  15. 15.

    Buonopane, A. & Petrakis, I. L. Subst. Use Misuse 40, 2001–2020 (2009).

    Article  Google Scholar 

Download references

Acknowledgements

F.I.S. is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the Emmy Noether Programme (SCHM 3336-1-1), SPP1923, SFB1403, TRR237 and Germany’s Excellence Strategy – EXC2151 – 390873048, as well as by the Klaus Tschira Boost Fund. E.L. is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through SPP1923, SFB1403, TRR237 and Germany’s Excellence Strategy – EXC2151 – 390873048.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Florian I. Schmidt.

Ethics declarations

Competing interests

E.L. is a cofounder of IFM Therapeutics. F.I.S. is a scientific consultant of IFM Therapeutics.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Schmidt, F.I., Latz, E. Jack of all trades inhibits inflammation (in sober people). Nat Immunol 21, 718–719 (2020). https://doi.org/10.1038/s41590-020-0693-6

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing