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CD36 — the Achilles’ heel of Treg cells

Regulatory T (Treg) cells suppress antitumor immunity, but Treg cell inhibition has been hampered by a lack of specific targets. CD36 expression by tumor-infiltrating Treg cells may provide a way to specifically target Treg cells in tumors.

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Fig. 1: Treg cells suppress effector T cells in the tumor microenvironment and in healthy tissues.


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Correspondence to Stefani Spranger.

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Horton, B.L., Spranger, S. CD36 — the Achilles’ heel of Treg cells. Nat Immunol 21, 251–253 (2020).

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