Oxidative stress in the tumor microenvironment activates expression of the phosphatase PAC1 in infiltrated T lymphocytes. PAC1 regulates the epigenetic modulator NuRD to limit the chromatin accessibility of T cell effector function genes, thereby fostering T cell exhaustion.
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Chan, S.C.L., Zhang, Y. PAC1-ing up the epigenetic landscape. Nat Immunol 21, 247–248 (2020). https://doi.org/10.1038/s41590-020-0594-8
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DOI: https://doi.org/10.1038/s41590-020-0594-8