Training the trainable cells of the immune system and beyond

The fourth Innate Immune Memory meeting was held in the historic city of Nijmegen, in the eastern-central part of the Netherlands, to discuss the basic and translational aspects of innate immune memory, popularly known as ‘trained immunity’.

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Fig. 1: Schematic representation of the concept of ‘training immunity’.

Debbie Maizels/Springer Nature

Change history

  • 11 March 2020

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

References

  1. 1.

    Netea, M. G. et al. Science 352, aaf1098 (2016).

  2. 2.

    Netea, M. G., Schlitzer, A., Placek, K., Joosten, L. A. B. & Schultze, J. L. Cell Host Microbe 25, 13–26 (2019).

  3. 3.

    Paust, S., Blish, C. A. & Reeves, R. K. J. Virol. 91, e00169–17 (2017).

  4. 4.

    van den Boorn, J. G. et al. Immunity 44, 1406–1421 (2016).

  5. 5.

    Paust, S. et al. Nat. Immunol. 11, 1127–1135 (2010).

  6. 6.

    Schlums, H. et al. Immunity 42, 443–456 (2015).

  7. 7.

    Yuan, R., Geng, S. & Li, L. Front. Immunol. 7, 497 (2016).

  8. 8.

    Kamada, R. et al. Proc. Natl Acad. Sci. USA 115, E9162–E9171 (2018).

  9. 9.

    Fanucchi, S. & Mhlanga, M. M. Front. Cell Dev. Biol. 7, 2 (2019).

  10. 10.

    Mitroulis, I. et al. Cell 172, 147–161.e12 (2018).

  11. 11.

    Leibundgut-Landmann, S., Osorio, F., Brown, G. D. & Reis e Sousa, C. Blood 112, 4971–4980 (2008).

  12. 12.

    Kaufmann, E. et al. Cell 172, 176–190.e19 (2018).

  13. 13.

    Saz-Leal, P. et al. Cell Rep. 25, 1118–1126 (2018).

  14. 14.

    Braza, M. S. et al. Immunity 49, 819–828.e6 (2018).

  15. 15.

    Dijkman, K. et al. Front. Immunol. 10, 2479 (2019).

  16. 16.

    Howard, N. C. et al. Nat. Microbiol. 3, 1099–1108 (2018).

  17. 17.

    Cirauqui, C. et al. Eur. J. Immunol. 48, 180–193 (2018).

  18. 18.

    Quinn, S. M. et al. Front. Immunol. 10, 1109 (2019).

  19. 19.

    Bomans, K. et al. Front. Immunol. 9, 2685 (2018).

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Correspondence to Upendra K. Kar.

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Kar, U.K., Joosten, L.A.B. Training the trainable cells of the immune system and beyond. Nat Immunol 21, 115–119 (2020). https://doi.org/10.1038/s41590-019-0583-y

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