Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

Human and translational immunology in the third millennium: progress, challenges and opportunities

Nature Immunology volume 20, pages 1568–1573 (2019)Cite this article

Subjects

Internationally renowned scientists gathered at the 2nd Human & Translational Immunology Conference in Kos, Greece, to discuss the latest advances in translational immunology, especially vaccinology, infectious diseases and tumor immunotherapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Approaches to improve vaccination efficiency presented at the 2nd Human & Translational Immunology Conference in Kos, Greece.
Fig. 2: Clinical applications of immunotherapy currently in practice.

References

  1. Bloom, D. E., Black, S., Salisbury, D. & Rappuoli, R. Proc. Natl Acad. Sci. USA 115, 12868–12871 (2018).

    Article  CAS  Google Scholar 

  2. Lynn, D. J. & Pulendran, B. J. Leukoc. Biol. 103, 225–231 (2018).

    CAS  PubMed  Google Scholar 

  3. Oh, J. Z. et al. Immunity 41, 478–492 (2014).

    Article  CAS  Google Scholar 

  4. Hagan, T. et al. Cell 178, 1313–1328.e1313 (2019).

    Article  CAS  Google Scholar 

  5. Penn-Nicholson, A. et al. Vaccine 33, 4025–4034 (2015).

    Article  CAS  Google Scholar 

  6. Onishi, M. et al. J. Immunol. 194, 2673–2682 (2015).

    Article  CAS  Google Scholar 

  7. Klechevsky, E. Adv. Exp. Med. Biol. 850, 43–54 (2015).

    Article  CAS  Google Scholar 

  8. Hawkridge, T. et al. J. Infect. Dis. 198, 544–552 (2008).

    Article  Google Scholar 

  9. Joosten, S. A. et al. Vaccine 37, 3022–3030 (2019).

    Article  CAS  Google Scholar 

  10. Melandri, D. et al. Nat. Immunol. 19, 1352–1365 (2018).

    Article  CAS  Google Scholar 

  11. Tomic, A. et al. J. Immunol. (2019).

  12. Lee, J. et al. Cell Host Microbe 25, 367–376.e365 (2019).

    Article  CAS  Google Scholar 

  13. Tan, J. et al. Nat. Med. 24, 401–407 (2018).

    Article  CAS  Google Scholar 

  14. Netea, M. G., Quintin, J. & van der Meer, J. W. Cell Host Microbe 9, 355–361 (2011).

    Article  CAS  Google Scholar 

  15. Arts, R. J. W. et al. Cell Host Microbe 23, 89–100.e105 (2018).

    Article  CAS  Google Scholar 

  16. Bekkering, S. et al. Cell 172, 135–146.e139 (2018).

    Article  CAS  Google Scholar 

  17. Dominguez-Andres, J. et al. Cell Metab. 29, 211–220.e215 (2019).

    Article  CAS  Google Scholar 

  18. Becattini, S. et al. Science 347, 400–406 (2015).

    Article  CAS  Google Scholar 

  19. Stelekati, E. et al. Cell Rep. 23, 2142–2156 (2018).

    Article  CAS  Google Scholar 

  20. Drolet, M., Benard, E., Perez, N. & Brisson, M. Lancet 394, 497–509 (2019).

    Article  Google Scholar 

  21. Sharma, P. & Allison, J. P. Science 348, 56–61 (2015).

    Article  CAS  Google Scholar 

  22. Samstein, R. M. et al. Nat. Genet. 51, 202–206 (2019).

    Article  CAS  Google Scholar 

  23. Martins, F. et al. Nat. Rev. Clin. Oncol. 16, 563–580 (2019).

    Article  CAS  Google Scholar 

  24. Brummelman, J. et al. J. Exp. Med. 215, 2520–2535 (2018).

    Article  CAS  Google Scholar 

  25. Korenfeld, D. et al. JCI Insight https://doi.org/10.1172/jci.insight.96101 (2017).

  26. Rodrigues, P. F. et al. Nat. Immunol. 19, 711–722 (2018).

    Article  CAS  Google Scholar 

  27. Kreiter, S. et al. Nature 520, 692–696 (2015).

    Article  CAS  Google Scholar 

  28. Stadler, C. R. et al. Nat. Med. 23, 815–817 (2017).

    Article  CAS  Google Scholar 

  29. Dubois, S., Mariner, J., Waldmann, T. A. & Tagaya, Y. Immunity 17, 537–547 (2002).

    Article  CAS  Google Scholar 

  30. Bergamaschi, C. et al. J. Biol. Chem. 283, 4189–4199 (2008).

    Article  CAS  Google Scholar 

  31. Soumelis, V. et al. Nat. Immunol. 3, 673–680 (2002).

    Article  CAS  Google Scholar 

  32. Corren, J. et al. N. Engl. J. Med. 377, 936–946 (2017).

    Article  CAS  Google Scholar 

  33. Koltsida, O. et al. EMBO Mol. Med. 3, 348–361 (2011).

    Article  CAS  Google Scholar 

  34. Galani, I. E. et al. Immunity 46, 875–890.e876 (2017).

    Article  CAS  Google Scholar 

  35. Andreakos, E., Zanoni, I. & Galani, I. E. Curr. Opin. Immunol. 56, 67–75 (2019).

    Article  CAS  Google Scholar 

  36. Alpert, A. et al. Nat. Med. 25, 487–495 (2019).

    Article  CAS  Google Scholar 

  37. Glanville, J. et al. Nature 547, 94–98 (2017).

    Article  CAS  Google Scholar 

  38. Saligrama, N. et al. Nature 572, 481–487 (2019).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank the organizers of the meeting (Peter Katsikis, Stephen Schoenberger, Bali Pulendran and Jamie D. K. Wilson) and the speakers for their useful feedback in preparing this Meeting Report. We also thank E. Alspach and X. Meshik (Washington University School of Medicine) for editorial input.

Author information

Author notes

  1. These authors contributed equally: Eynav Klechevsky, Evangelos Andreakos.

Authors and Affiliations

  1. Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

    Ioanna E. Galani & Evangelos Andreakos

  2. Department of Pathology and Immunology, division of immunobiology, Washington University School of Medicine, St. Louis, MO, USA

    Eynav Klechevsky

Authors
  1. Ioanna E. Galani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eynav Klechevsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Evangelos Andreakos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Eynav Klechevsky or Evangelos Andreakos.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Galani, I.E., Klechevsky, E. & Andreakos, E. Human and translational immunology in the third millennium: progress, challenges and opportunities. Nat Immunol 20, 1568–1573 (2019). https://doi.org/10.1038/s41590-019-0543-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0543-6

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer