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PROTEIN EVOLUTION

Too much can be as bad as too little

Nature Immunology volume 20, pages 1262–1264 (2019)Cite this article

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Transcription-factor paralogs are not equivalent and serve distinct roles in immune cells. Analysis of the RUNX family of transcription factors reveals insights into the non-redundant roles of RUNX1 and RUNX3.

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Fig. 1: Adaptation toward sub-maximal transcription-factor strength.

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Authors and Affiliations

  1. Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

    Wooseok Seo & Ichiro Taniuchi

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  1. Wooseok Seo
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  2. Ichiro Taniuchi
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Correspondence to Ichiro Taniuchi.

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The authors declare no competing interests.

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Seo, W., Taniuchi, I. Too much can be as bad as too little. Nat Immunol 20, 1262–1264 (2019). https://doi.org/10.1038/s41590-019-0498-7

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