Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

ZIKA VACCINE

When it is better to stay together

Nature Immunology volume 20, pages 1266–1268 (2019)Cite this article

Subjects

A specifically engineered Zika subunit vaccine based on the viral envelope protein mediates protective immunity in mice without inducing the cross-reactive antibodies responsible for antibody-dependent enhancement of infection with dengue virus.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Structural background for the Zika E dimer vaccine stabilized by three disulfide bridges to prevent E dimer dissociation and exposure of the fusion loop.

References

  1. Richner, J. M. & Diamond, M. S. Curr. Opin. Immunol. 53, 130–136 (2018).

    Article  CAS  Google Scholar 

  2. Slon-Campos, J.L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0477-z (2019).

  3. Rey, F. A., Stiasny, K., Vaney, M. C., Dellarole, M. & Heinz, F. X. EMBO Rep. 19, 206–224 (2018).

    Article  CAS  Google Scholar 

  4. Dowd, K. A. & Pierson, T. C. Annu. Rev. Virol. 5, 185–207 (2018).

    Article  CAS  Google Scholar 

  5. Barba-Spaeth, G. et al. Nature 536, 48–53 (2016).

    Article  CAS  Google Scholar 

  6. Dejnirattisai, W. et al. Nat. Immunol. 17, 1102–1108 (2016).

    Article  CAS  Google Scholar 

  7. Fernandez, E. et al. Nat. Immunol. 18, 1261–1269 (2017).

    Article  CAS  Google Scholar 

  8. Richner, J. M. et al. Cell 168, 1114–1125.e10 (2017).

    Article  CAS  Google Scholar 

  9. Pierson, T. C. et al. Cell Host Microbe 1, 135–145 (2007).

    Article  CAS  Google Scholar 

  10. Shim, B.-S. et al. MBio 10, e00758–19 (2019).

    PubMed  PubMed Central  Google Scholar 

  11. Snapper, C. M. Front. Immunol. 9, 598–598 (2018).

    Article  Google Scholar 

  12. Prasad, V. M. et al. Nat. Struct. Mol. Biol. 24, 184–186 (2017).

    Article  CAS  Google Scholar 

  13. Sevvana, M. et al. Structure 26, 1169–1177.e3 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Virology, Medical University of Vienna, Vienna, Austria

    Franz X. Heinz & Karin Stiasny

Authors
  1. Franz X. Heinz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Karin Stiasny
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Franz X. Heinz.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Heinz, F.X., Stiasny, K. When it is better to stay together. Nat Immunol 20, 1266–1268 (2019). https://doi.org/10.1038/s41590-019-0497-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0497-8

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing