The transcription factor TOX epigenetically reprograms CD8+ T cells to drive T cell exhaustion during chronic infection and cancer. Although they are necessary for T cell persistence, these changes contribute to diminished anti-tumor function in exhausted cells.
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References
Scott, A.C. et al. Nature https://doi.org/10.1038/s41586-019-1324-y (2019).
Khan, O. et al. Nature https://doi.org/10.1038/s41586-019-1325-x (2019).
Alfei, F. et al. Nature https://doi.org/10.1038/s41586-019-1326-9 (2019).
Yao, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0403-4 (2019).
Seo, H. et al. Proc. Natl Acad. Sci. USA https://doi.org/10.1073/pnas.1905675116 (2019).
Wherry, E. J. & Kurachi, M. Nat. Rev. Immunol. 15, 486–499 (2015).
Paley, M. A. et al. Science 338, 1220–1225 (2012).
Im, S. J. et al. Nature 537, 417–421 (2016).
Pauken, K. E. et al. Science 354, 1160–1165 (2016).
Ghoneim, H. E. et al. Cell 170, 142–157.e19 (2017).
Zhou, X. et al. Immunity 33, 229–240 (2010).
Siddiqui, I. et al. Immunity 50, 195–211.e10 (2019).
Page, N. et al. Immunity 48, 937–950.e8 (2018).
Sanjabi, S., Mosaheb, M. M. & Flavell, R. A. Immunity 31, 131–144 (2009).
Martinez, G. J. et al. Immunity 42, 265–278 (2015).
Chen, J. et al. Nature 567, 530–534 (2019).
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Mann, T.H., Kaech, S.M. Tick-TOX, it’s time for T cell exhaustion. Nat Immunol 20, 1092–1094 (2019). https://doi.org/10.1038/s41590-019-0478-y
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DOI: https://doi.org/10.1038/s41590-019-0478-y
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