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CANCER IMMUNOLOGY

Treg cell IL-10 and IL-35 exhaust CD8+ T cells in tumors

Expression of the immunosuppressive cytokines IL-10 and IL-35 by tumor-infiltrating regulatory T cells drives exhaustion of intratumoral CD8+ T cells through a common pathway dependent on the transcription factor BLIMP-1.

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The authors declare no competing interests.

Correspondence to Nikhil S. Joshi.

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Fig. 1: Treg cells use IL-10 and IL-35 to drive CD8+ T cell exhaustion in tumors.