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Fighting influenza through hemagglutinin diversity

Nature Immunologyvolume 20pages246247 (2019) | Download Citation

A multivalent vaccine that presents diverse influenza virus subtype H1 hemagglutinins on its surface induces broadly neutralizing antibodies in an animal model by displaying conserved epitopes at higher density than strain-specific epitopes.

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References

  1. 1.

    Kanekiyo, M. et al. Nat. Immunol. https://doi.org/10.1038/s41559-018-0305-x (2019).

  2. 2.

    Krammer, F. Expert Rev. Vaccines 16, 503–513 (2017).

  3. 3.

    Pica, N. et al. Proc. Natl Acad. Sci. USA 109, 2573–2578 (2012).

  4. 4.

    Andrews, S. F. et al. Sci. Transl. Med. 7, 316ra192 (2015).

  5. 5.

    Anderson, A. M., Baranowska-Hustad, M., Braathen, R., Grodeland, G. & Bogen, B. J. Immunol. 200, 2057–2066 (2018).

  6. 6.

    Kirkpatrick, E., Qiu, X., Wilson, P. C., Bahl, J. & Krammer, F. Sci. Rep. 8, 10432 (2018).

  7. 7.

    Broecker, F. et al. J. Virol. 92, e01100-18 (2018).

  8. 8.

    Liu, S. T. H. et al. J. Clin. Invest. 128, 4992–4996 (2018).

  9. 9.

    Sun, W. et al. J. Virol. 93, e01673-18 (2018).

  10. 10.

    Garretson, T. A., Petrie, J. G., Martin, E. T., Monto, A. S. & Hensley, S. E. Vaccine 36, 4095–4101 (2018).

  11. 11.

    Woodruff, M. C., Kim, E. H., Luo, W. & Pulendran, B. Cell Rep. 25, 321–327 (2018).

  12. 12.

    Ekiert, D. C. et al. Nature 489, 526–532 (2012).

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Author information

Affiliations

  1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    • Florian Krammer

Authors

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Competing interests

The Icahn School of Medicine at Mount Sinai has filed patent applications for vaccines against influenza virus that name F.K. as an inventor. The Krammer laboratory currently receives funding from the Bill and Melinda Gates Foundation, the US Department of Defense, PATH, the US National Institute of Allergy and Infectious Diseases and GlaxoSmithKline for research on vaccines against influenza virus.

Corresponding author

Correspondence to Florian Krammer.

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DOI

https://doi.org/10.1038/s41590-019-0317-1

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