Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Remote control of γc expression by arginine methylation

Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells by a post-transcriptional mechanism.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: The ‘butterfly effect’ of arginine methylation on the expression of and signaling via γc cytokine receptors.


  1. 1.

    Waickman, A. T., Park, J. Y. & Park, J. H. Cell. Mol. Life Sci. 73, 253–269 (2016).

    CAS  Article  Google Scholar 

  2. 2.

    Inoue, M. et al. Nat. Immunol. (2018).

    Article  Google Scholar 

  3. 3.

    Blanc, R. S. & Richard, S. Mol. Cell 65, 8–24 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Geoghegan, V., Guo, A., Trudgian, D., Thomas, B. & Acuto, O. Nat. Commun. 6, 6758 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    Liu, F. et al. J. Clin. Invest. 125, 3532–3544 (2015).

    Article  Google Scholar 

  6. 6.

    Tee, W. W. et al. Genes Dev. 24, 2772–2777 (2010).

    CAS  Article  Google Scholar 

  7. 7.

    Bendelac, A., Savage, P. B. & Teyton, L. Annu. Rev. Immunol. 25, 297–336 (2007).

    CAS  Article  Google Scholar 

  8. 8.

    Bezzi, M. et al. Genes Dev. 27, 1903–1916 (2013).

    CAS  Article  Google Scholar 

  9. 9.

    Friesen, W. J., Massenet, S., Paushkin, S., Wyce, A. & Dreyfuss, G. Mol. Cell 7, 1111–1117 (2001).

    CAS  Article  Google Scholar 

  10. 10.

    Hong, C. et al. Immunity 40, 910–923 (2014).

    CAS  Article  Google Scholar 

  11. 11.

    Markiewicz, S. et al. J. Biol. Chem. 271, 14849–14855 (1996).

    CAS  Article  Google Scholar 

  12. 12.

    McCaughtry, T. M. et al. J. Exp. Med. 209, 2263–2276 (2012).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Jung-Hyun Park.

Ethics declarations

Competing interests

The authors declare no competing interests

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Park, JY., Park, JH. Remote control of γc expression by arginine methylation. Nat Immunol 19, 1152–1154 (2018).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing