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ANTITUMOR RESPONSES

γδ T cells and IgE team up to prevent tumors

In response to epithelial DNA damage, tissue-resident γδ T cells initiate and shape a tumor-protective IgE response that requires CD4+ T cells and immune effector cells expressing the high-affinity IgE receptor FcεRI.

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Fig. 1: Skin-resident γδ T cells sense epithelial damage and help shape a tumor-protective IgE response.

Marina Corral Spence/Springer Nature

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Correspondence to Wendy L. Havran.

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McGraw, J.M., Havran, W.L. γδ T cells and IgE team up to prevent tumors. Nat Immunol 19, 793–795 (2018). https://doi.org/10.1038/s41590-018-0167-2

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