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ANTITUMOR RESPONSES

γδ T cells and IgE team up to prevent tumors

Nature Immunologyvolume 19pages793795 (2018) | Download Citation

In response to epithelial DNA damage, tissue-resident γδ T cells initiate and shape a tumor-protective IgE response that requires CD4+ T cells and immune effector cells expressing the high-affinity IgE receptor FcεRI.

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Author information

Affiliations

  1. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA

    • J. Michael McGraw
    •  & Wendy L. Havran

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Wendy L. Havran.

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DOI

https://doi.org/10.1038/s41590-018-0167-2

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