Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

VACCINATION

Dysbiosis shapes vaccine responses

Cell Host Microbe https://doi.org/10.1016/j.chom.2018.04.009 (2018)

Vaccine responses can vary considerably among people, with both genetic factors and environmental factors exerting an influence. In Cell Host and Microbe, Lynn and colleagues use a mouse model to assess the effect of early-life exposure to antibiotics (ampicillin and neomycin) on responses to five different vaccines. In all cases, early exposure to antibiotics results in impaired antibody responses. In contrast, T cell cytokine responses are intact or even enhanced. Exposure of adult mice to antibiotics does not impair vaccine responses. The impairment of antibody responses seems to be dependent on antibiotic-driven dysbiosis rather than on direct effects of the antibiotics themselves. Understanding the microbiotal factors that shape vaccine responses might help in the tailoring of vaccinations, such as by the inclusion of probiotics.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Zoltan Fehervari.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Fehervari, Z. Dysbiosis shapes vaccine responses. Nat Immunol 19, 647 (2018). https://doi.org/10.1038/s41590-018-0151-x

Download citation

Search

Quick links