News & Views | Published:

T CELL MOTILITY

CCR7 fuels and LFA-1 grips

Nature Immunologyvolume 19pages516518 (2018) | Download Citation

Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Schulz, O., Hammerschmidt, S. I., Moschovakis, G. L. & Forster, R. Annu. Rev. Immunol. 34, 203–242 (2016).

  2. 2.

    Alon, R. & Dustin, M. L. Immunity 26, 17–27 (2007).

  3. 3.

    Springer, T. A. & Dustin, M. L. Curr. Opin. Cell Biol. 24, 107–115 (2012).

  4. 4.

    Woolf, E. et al. Nat. Immunol. 8, 1076–1085 (2007).

  5. 5.

    Worbs, T., Mempel, T. R., Bolter, J., von Andrian, U. H. & Forster, R. J. Exp. Med. 204, 489–495 (2007).

  6. 6.

    Hons, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0109-z (2018).

  7. 7.

    Paluch, E. K., Aspalter, I. M. & Sixt, M. Annu. Rev. Cell Dev. Biol. 32, 469–490 (2016).

  8. 8.

    Nordenfelt, P. et al. Nat. Commun. 8, 2047 (2017).

  9. 9.

    Jacobelli, J., Bennett, F. C., Pandurangi, P., Tooley, A. J. & Krummel, M. F. J. Immunol. 182, 2041–2050 (2009).

  10. 10.

    Overstreet, M. G. et al. Nat. Immunol. 14, 949–958 (2013).

  11. 11.

    Walch, J. M. et al. J. Clin. Invest. 123, 2663–2671 (2013).

  12. 12.

    Hickman, H. D. et al. Immunity 42, 524–537 (2015).

  13. 13.

    Te Boekhorst, V., Preziosi, L. & Friedl, P. Annu. Rev. Cell Dev. Biol. 32, 491–526 (2016).

Download references

Author information

Affiliations

  1. Department of Physics and Astronomy and Department of Biology, University of Rochester, Rochester, NY, USA

    • Patrick W. Oakes
  2. David H. Smith Center for Vaccine Biology and immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA

    • Deborah J. Fowell

Authors

  1. Search for Patrick W. Oakes in:

  2. Search for Deborah J. Fowell in:

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Deborah J. Fowell.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41590-018-0118-y

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing