The metabolic master regulator mTORC1 is shown to promote alternative macrophage activation via Semaphorin 6D reverse signaling and reprogramming of lipid metabolism.
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References
Kang, S. et al. A. Nat. Immunol. https://doi.org/10.1038/s41590-018-0108-0 (2018).
Murray, P. J. et al. Immunity 41, 14–20 (2014).
Weichhart, T., Hengstschläger, M. & Linke, M. Nat. Rev. Immunol. 15, 599–614 (2015).
Kimura, T. et al. Nat. Commun. 7, 13130 (2016).
Covarrubias, A.J. et al. eLife 5, e11612 (2016).
Worzfeld, T. & Offermanns, S. Nat. Rev. Drug Discov. 13, 603–621 (2014).
Toyofuku, T. et al. Nat. Cell Biol. 6, 1204–1211 (2004).
Mercalli, A. et al. Immunology 140, 179–190 (2013).
Byles, V. et al. Nat. Commun. 4, 2834 (2013).
Zhu, L. et al. Nat. Commun. 5, 4696 (2014).
Linke, M. et al. Nat. Immunol. 18, 293–302 (2017).
Fang, C. et al. Cell. Physiol. Biochem. 36, 1406–1418 (2015). (2018).
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Wilson, J.L., Weichhart, T. TORching a semaphore for alternative macrophage activation. Nat Immunol 19, 512–514 (2018). https://doi.org/10.1038/s41590-018-0117-z
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DOI: https://doi.org/10.1038/s41590-018-0117-z