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γδ17 T CELLS

Got my γδ17 T cells to keep me warm

γδ T cells accumulate with age in adipose tissue and produce the cytokine IL-17, which controls the homeostasis of regulatory T cells and adaptive thermogenesis. Thus, maintenance of core body temperature unexpectedly relies on these adipose tissue–resident γδ17 T cells.

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Fig. 1: Adipose tissue–resident γδ T cells secrete IL-17 and TNF, which control thermogenesis.

Katie Vicari/Springer Nature

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Correspondence to Bruno Silva-Santos.

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Papotto, P.H., Silva-Santos, B. Got my γδ17 T cells to keep me warm. Nat Immunol 19, 427–429 (2018). https://doi.org/10.1038/s41590-018-0090-6

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