The sensing of viable pathogens by the receptor TLR8 on human monocytes provides key signals that initiate the differentiation of naive CD4+ T cells into follicular helper T cells. Targeting TLR8 might represent a novel approach for improving immunity following vaccination.
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References
Amanna, I. J. & Slifka, M. K. Antiviral Res. 84, 119–130 (2009).
Slifka, M. K. & Amanna, I. Vaccine 32, 2948–2957 (2014).
De Gregorio, E. & Rappuoli, R. Nat. Rev. Immunol. 14, 505–514 (2014).
Ugolini, M. Nat. Immunol. https://doi.org/10.1038/s41590-018-0068-4 (2018).
Crotty, S. Immunity 41, 529–542 (2014).
Tangye, S. G., Ma, C. S., Brink, R. & Deenick, E. K. Nat. Rev. Immunol. 13, 412–426 (2013).
Ma, C. S. et al. Blood 119, 3997–4008 (2012).
Schmitt, N. et al. Immunity 31, 158–169 (2009).
Ma, C. S. et al. J. Exp. Med. 213, 1589–1608 (2016).
Hartmann, G. Adv. Immunol. 133, 121–169 (2017).
Oh, D. Y. et al. J. Infect. Dis. 198, 701–709 (2008).
Picard, C., Casanova, J. L. & Puel, A. Clin. Microbiol. Rev. 24, 490–497 (2011).
Schmitt, N. et al. Blood 121, 3375–3385 (2013).
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Tangye, S.G. Is it dead or alive? TLR8 can tell. Nat Immunol 19, 324–326 (2018). https://doi.org/10.1038/s41590-018-0070-x
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DOI: https://doi.org/10.1038/s41590-018-0070-x