INDUCED HEMATOPOIESIS

Hoxb5, a Trojan horse to generate T cells

The transcription factor Hoxb5 is expressed specifically in hematopoietic stem cells, yet its ectopic expression in mouse B cell progenitors induces their conversion into functional T cells in vivo.

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Fig. 1: Ectopic expression of the HSC-specific transcription factor Hoxb5 can directly convert B cells into functional T cells in vivo.

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Correspondence to Thomas Graf.

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Stik, G., Graf, T. Hoxb5, a Trojan horse to generate T cells. Nat Immunol 19, 210–212 (2018). https://doi.org/10.1038/s41590-018-0053-y

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