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INDUCED HEMATOPOIESIS

Hoxb5, a Trojan horse to generate T cells

Nature Immunology volume 19, pages 210–212 (2018)Cite this article

The transcription factor Hoxb5 is expressed specifically in hematopoietic stem cells, yet its ectopic expression in mouse B cell progenitors induces their conversion into functional T cells in vivo.

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Fig. 1: Ectopic expression of the HSC-specific transcription factor Hoxb5 can directly convert B cells into functional T cells in vivo.

References

  1. Daniel, M. G., Pereira, C. F., Lemischka, I. R. & Moore, K. A. Trends Cell Biol. 26, 202–214 (2016).

    Article  PubMed  Google Scholar 

  2. Lis, R. et al. Nature 545, 439–445 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sugimura, R. et al. Nature 545, 432–438 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Zhang, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0046-x (2017).

  5. Xie, H., Ye, M., Feng, R. & Graf, T. Cell 117, 663–676 (2004).

    Article  CAS  PubMed  Google Scholar 

  6. Di Stefano, B. et al. Nature 506, 235–239 (2014).

    Article  PubMed  Google Scholar 

  7. Riddell, J. et al. Cell 157, 549–564 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Chen, J. Y. et al. Nature 530, 223–227 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Cobaleda, C., Jochum, W. & Busslinger, M. Nature 449, 473–477 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Nutt, S. L., Heavey, B., Rolink, A. G. & Busslinger, M. Nature 401, 556–562 (1999).

    Article  CAS  PubMed  Google Scholar 

  11. Bijl, J. et al. Blood 108, 116–122 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Schmitt, T. M. & Zúñiga-Pflücker, J. C. Immunity 17, 749–756 (2002).

    Article  CAS  PubMed  Google Scholar 

  13. Bian, Q. & Cahan, P. Trends Biotechnol. 34, 993–1009 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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  1. Center for Genomic Regulation, The Barcelona Institute of Science and Technology and Universitat Pompeu Fabra, Barcelona, Spain

    Gregoire Stik & Thomas Graf

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  1. Gregoire Stik
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  2. Thomas Graf
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Correspondence to Thomas Graf.

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Stik, G., Graf, T. Hoxb5, a Trojan horse to generate T cells. Nat Immunol 19, 210–212 (2018). https://doi.org/10.1038/s41590-018-0053-y

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