Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome. ATGL has now been identified as a negative regulator of this pathway that dampens inflammation by removing LPS’ acyl chains, preventing the activation of inflammatory caspases and cytokines.
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Banister, G., Boucher, D. LPS gets a fresh trim. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01589-2
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DOI: https://doi.org/10.1038/s41589-024-01589-2