Antigen loading onto class I major histocompatibility complex (MHC-I) proteins relies on chaperones and protein flexibility. Researchers now provide new insight into the process, especially for the intriguing ‘non-classical’ MHC-I protein MR1, with implications for fundamental immunology and the development of novel immunotherapies.
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Rosales, T.J., Baker, B.M. Chaperoning the dance of antigen presentation. Nat Chem Biol 18, 796–797 (2022). https://doi.org/10.1038/s41589-022-01069-5
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DOI: https://doi.org/10.1038/s41589-022-01069-5
