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NON-CODING RNA

Growing a garden of fluorescent RNAs

Reliable quantification and tracing of RNA molecules remain challenging goals. A new fluorescent RNA tag, developed based on a natural adenine-sensing riboswitch and named Squash, offers superior imaging properties and accurate quantification in living cells.

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Fig. 1: Application and features of Spinach.

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Correspondence to Alexander Serganov.

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Kaushik, A., Nuthanakanti, A. & Serganov, A. Growing a garden of fluorescent RNAs. Nat Chem Biol 18, 120–122 (2022). https://doi.org/10.1038/s41589-021-00921-4

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