The uninhibited pathway is not worth studying

Glucose 6-phosphate dehydrogenase (G6PD) stands at the head of the pentose phosphate pathway, which is responsible for nucleotide synthesis. The identification and thorough validation of an improved G6PD inhibitor provide a valuable new tool compound for studying metabolism.

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Fig. 1: The parallel glycolysis and pentose phosphate pathways in a T cell.


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Correspondence to Michael E. Pacold.

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Competing interests

M.E.P. is a consultant to and holds equity in Raze Therapeutics and is the recipient of travel funds from Thermo Fisher Scientific.

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Pacold, M.E. The uninhibited pathway is not worth studying. Nat Chem Biol 16, 713–714 (2020).

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