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mTORC1 SIGNALING

Clearing debris

A new small molecule that targets the vacuolar H+-ATPase activates autophagy, inhibits mTORC1 signaling, and displays potential for clearing toxic protein aggregates involved in neurodegenerative diseases.

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Correspondence to Jenna L. Jewell.

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Fig. 1: EN6 promotes autophagy by enhancing vacuolar H+-ATPase (v-ATPase) activity and inhibiting mTORC1 signaling.