The carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) is post-translationally modified during gene expression. A recent study has identified a CTD kinase, Hrr25, that regulates the termination of noncoding RNA genes by recruiting Rtt103, a key termination factor.
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References
Allison, L. A., Moyle, M., Shales, M. & Ingles, C. J. Cell 42, 599–610 (1985).
Corden, J. L., Cadena, D. L., Ahearn, J. M. Jr. & Dahmus, M. E. Proc. Natl Acad. Sci. USA 82, 7934–7938 (1985).
Harlen, K. M. & Churchman, L. S. Nat. Rev. Mol. Cell Biol. 18, 263–273 (2017).
Nemec, C. S. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0194-1 (2018).
Buratowski, S. Mol. Cell 36, 541–546 (2009).
Nemec, C. M. et al. Proc. Natl Acad. Sci. USA 114, E3944–E3953 (2017).
Phatnani, H. P., Jones, J. C. & Greenleaf, A. L. Biochemistry 43, 15702–15719 (2004).
Bhatt, D. M. et al. Cell 150, 279–290 (2012).
Hintermair, C. et al. EMBO J. 31, 2784–2797 (2012).
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Genes Robles, C.M., Coin, F. Conducting the CTD orchestra. Nat Chem Biol 15, 97–98 (2019). https://doi.org/10.1038/s41589-018-0201-6
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DOI: https://doi.org/10.1038/s41589-018-0201-6
