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Chromatin organization

Building chromatin from the ground up

Nature Genetics volume 56, pages 360–361 (2024)Cite this article

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A common architectural feature of the genome in many organisms is chromatin domains. A synthetic biology approach now builds chromatin domains from scratch and identifies some of the minimal components needed for their formation.

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Fig. 1: An approach to build chromatin in vitro.

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Authors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Theodore Busby III & Tom Misteli

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  1. Theodore Busby III
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  2. Tom Misteli
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Correspondence to Tom Misteli.

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The authors declare no competing interests.

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Busby, T., Misteli, T. Building chromatin from the ground up. Nat Genet 56, 360–361 (2024). https://doi.org/10.1038/s41588-024-01666-1

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