Matched single-cell transcriptomic and epigenomic profiles obtained from human scalp reveal gene regulatory maps of diverse cell types in the hair follicle niche. Integrating these data with existing genome-wide association studies enabled prioritization of cell types, genes, and causal variants implicated in the pathobiology of androgenetic alopecia, eczema, and other complex traits.
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This is a summary of: Ober-Reynolds, B. et al. Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases. Nat. Genet. https://doi.org/10.1038/s41588-023-01445-4 (2023).
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Identifying critical cell types and gene regulatory pathways for hair and skin disease. Nat Genet 55, 1263–1264 (2023). https://doi.org/10.1038/s41588-023-01447-2
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DOI: https://doi.org/10.1038/s41588-023-01447-2
