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Diabetes

Dynamic measures of insulin action identify genetic determinants of dysglycemia

Nature Genetics volume 55, pages 905–907 (2023)Cite this article

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Genome-wide association studies (GWAS) of type 2 diabetes have identified few loci connected to muscle biology. A GWAS of post-glucose-challenge measures of insulin has now identified loci related to insulin resistance and GLUT4 regulation in skeletal muscle, illustrating the benefit of studying dynamic glycemic measures.

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Fig. 1: GWAS of measures of insulin action following glucose challenge identify loci related to insulin resistance, including SLC2A4.

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Authors and Affiliations

  1. Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA

    Miriam S. Udler

  2. Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Miriam S. Udler

  3. Department of Medicine, Harvard Medical School, Boston, MA, USA

    Miriam S. Udler

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  1. Miriam S. Udler
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Correspondence to Miriam S. Udler.

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Udler, M.S. Dynamic measures of insulin action identify genetic determinants of dysglycemia. Nat Genet 55, 905–907 (2023). https://doi.org/10.1038/s41588-023-01346-6

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