Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Chromatin regulation

Chromatin oxygen sensing by histone H3 prolyl hydroxylation

Nature Genetics volume 54, pages 1585–1586 (2022)Cite this article

Subjects

A new study identifies prolyl hydroxylation of histone H3 as a signal for the recruitment of KDM5A, altering H3K4me3 and gene expression. H3P16oh is independent of the HIF hypoxia-sensing pathway and provides a further layer of complexity to oxygen-sensitive chromatin modifications.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Hypoxic regulation of H3K4me3 by KDM5A and PHD1.

References

  1. Kaelin, W. G. Jr. & Ratcliffe, P. J. Mol. Cell 30, 393–402 (2008).

    Article  CAS  PubMed  Google Scholar 

  2. Semenza, G. L. Cell 148, 399–408 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ivan, M. & Kaelin, W. G. Jr Mol. Cell 66, 772–779 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Liu, X. et al. Nat. Genet. https://doi.org/10.1038/s41588-022-01212-x (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Howe, F. S. et al. Mol. Cell 55, 733–744 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Nelson, C. J., Santos-Rosa, H. & Kouzarides, T. Cell 126, 905–916 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Cockman, M. E. et al. eLife 8, e46490 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Cano-Rodriguez, D. et al. Nat. Commun. 7, 12284 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Douillet, D. et al. Nat. Genet. 52, 615–625 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Brown, D. A. et al. Cell Rep. 20, 2313–2327 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Chakraborty, A. A. et al. Science 363, 1217–1222 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Batie, M. et al. Science 363, 1222–1226 (2019).

    Article  CAS  PubMed  Google Scholar 

  13. Thienpont, B. et al. Nature 537, 63–68 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Ortmann, B. M. et al. Nat. Genet. 53, 1022–1035 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Dion, M. F. et al. Science 315, 1405–1408 (2007).

    Article  CAS  PubMed  Google Scholar 

  16. Ferrari, P. & Strubin, M. Nucleic Acids Res. 43, 3972–3985 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, UK

    James A. Nathan

Authors
  1. James A. Nathan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to James A. Nathan.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nathan, J.A. Chromatin oxygen sensing by histone H3 prolyl hydroxylation. Nat Genet 54, 1585–1586 (2022). https://doi.org/10.1038/s41588-022-01201-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-022-01201-0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing