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DRIVER MUTATIONS

Shining light on dark selection in healthy human tissues

The genomes of cells across human tissues are riddled by changes to their DNA1,2,3. Many of these mutations do not alter the properties of a cell, and are neutral passengers. However, a small proportion can change a cell’s fitness, and increase or decrease the progeny that originate from the mutated cell4. How many of these alterations under positive selection (drivers) exist in total is unknown. Whether the current list of drivers is almost complete, or whether large proportions of positively selected drivers in the human genome remain undetected is yet to be determined.

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Fig. 1: Mutational mosaics in healthy human tissues.

References

  1. 1.

    Martincorena, I. et al. Science 348, 880–886 (2015).

    CAS  Article  Google Scholar 

  2. 2.

    Martincorena, I. et al. Science 362, 911–917 (2018).

    CAS  Article  Google Scholar 

  3. 3.

    Lee-Six, H. et al. Nature 561, 473–478 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Watson, C. et al. Science 367, 1449–1454 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Poon, G. Y. P., Watson, C. J., Fisher, D. S. & Blundell, J. R. Nat. Genet. https://doi.org/10.1038/s41588-021-00957-1 (2021).

    Article  Google Scholar 

  6. 6.

    Ju, Y. S. et al. Nature 543, 714–718 (2017).

    CAS  Article  Google Scholar 

  7. 7.

    Mitchell, E. et al. Preprint at https://doi.org/10.1101/2021.08.16.456475 (2021).

  8. 8.

    Williams, M.J. et al. Preprint at https://doi.org/10.1101/2021.06.04.447031 (2021).

  9. 9.

    Nam, A. S., Chaligne, R. & Landau, D. A. Nat. Rev. Genet. 22, 3–18 (2021).

    CAS  Article  Google Scholar 

  10. 10.

    Izzo, F. et al. Nat. Genet. 52, 378–387 (2020).

    CAS  Article  Google Scholar 

  11. 11.

    Williams, M. J. et al. Nat. Genet. 50, 895–903 (2018).

    CAS  Article  Google Scholar 

  12. 12.

    Fabre, M. A. et al. Preprint at https://doi.org/10.1101/2021.08.12.455048 (2021).

Download references

Acknowledgements

B.W. is funded by a Barts Charity Lectureship (grant MGU045).

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Correspondence to Benjamin Werner.

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Werner, B. Shining light on dark selection in healthy human tissues. Nat Genet 53, 1525–1526 (2021). https://doi.org/10.1038/s41588-021-00959-z

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