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Exploring tRNAs and their modifications and crosstalk using Nano-tRNAseq


Nano-tRNAseq is a nanopore-based, cost-effective and high-throughput approach to quantify transfer RNA (tRNA) abundances and modifications simultaneously, providing a framework to study the ‘tRNAome’ at single-molecule resolution. We envision that Nano-tRNAseq will enable us to study the role of tRNA molecules and their modifications in a wide variety of contexts.

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Fig. 1: Nano-tRNAseq quantifies tRNA abundances and modifications.


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This is a summary of: Lucas, M. C. et al. Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing. Nat. Biotechnol. (2023).

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Exploring tRNAs and their modifications and crosstalk using Nano-tRNAseq. Nat Biotechnol (2023).

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