We present the Schmidt objective, a novel astronomy-inspired concept for designing multi-immersion microscope objectives with high numerical aperture, long working distance and large field of view. The Schmidt objective uses a spherical mirror and a correction plate to focus light. It is well suited for high-resolution imaging deep inside cleared biological samples.
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Richardson, D. S. et al. Tissue clearing. Nat Rev. Methods Primers 1, 84 (2021). This review article presents an overview of tissue clearing.
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Schmidt, B. Ein lichtstarkes komafreies Spiegelsystem. Zentral-Zeitung für Optik und Mechanik 52(Heft 2), 25–26 (1931). This paper is describes the Schmidt telescope, invented in 1930 by the Estonian-born optician and astronomer Bernhard Schmidt (1879–1935).
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This is a summary of: Voigt, F. F. et al. Reflective multi-immersion microscope objectives inspired by the Schmidt telescope. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01717-8 (2023).
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Imaging the biological microcosmos with a tiny telescope. Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-01740-9