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Profiling chromatin–protein crosstalk at locus resolution in single cells

Nature Biotechnology volume 41, pages 624–625 (2023)Cite this article

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Development is orchestrated in part by myriad chromatin-associated proteins that decorate the genome and physically coordinate in ways that are often unclear. An epigenomics technique called MulTI-Tag maps the genomic locations of different chromatin proteins in the same individual cells, helping to unveil their interactions.

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Fig. 1: MulTI-Tag epigenome profiling.

References

  1. Kaya-Okur, H. S. et al. CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat. Protoc. 10, 1930 (2019). Describes CUT&Tag, an antibody-guided Tn5 tagmentation-based epigenome profiling technique.

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  2. Bernstein, B. E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315–326 (2006). Reports the first observation of ‘bivalent’ chromatin characterized by active (H3K4me3) and repressive (H3K27me3) histone modifications co-enriched in the same genes.

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This is a summary of: Meers, M. P., Llagas, G., Janssens, D. H., Codomo, C. A. & Henikoff, S. Multifactorial profiling of epigenetic landscapes at single-cell resolution using MulTI-Tag. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01522-9 (2022)

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Profiling chromatin–protein crosstalk at locus resolution in single cells. Nat Biotechnol 41, 624–625 (2023). https://doi.org/10.1038/s41587-022-01557-y

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