Post-translational modifications (PTMs) alter the structure, properties and functions of proteins in all aspects of biology. A new computational pipeline, termed protein modification integrated search engine (PROMISE), reveals the impact these modifications might have on the presentation of cancer antigens to T cells.
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This is a summary of: Kacen, A. et al. Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01464-2 (2022)
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Capturing the diversity of protein modifications on presented tumor antigens. Nat Biotechnol 41, 195–196 (2023). https://doi.org/10.1038/s41587-022-01465-1
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DOI: https://doi.org/10.1038/s41587-022-01465-1
