Drug combinations predicted to increase tumor cell death directly and by creating strong antitumor tumor microenvironments were identified by computational analysis of local responses to combinations of anticancer drugs delivered inside a tumor. Such predicted drug combinations were highly effective when administered systemically in mouse models of breast cancer.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jonas, O. et al. An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors. Sci. Transl. Med. 7, 284ra57 (2015). This article provides background on and technical validation of the implantable microdevices used in this study.
Dominas, C. et al. The translational and regulatory development of an implantable microdevice for multiple drug sensitivity measurements in cancer patients. IEEE Trans. Biomed. Eng. 69, 412–421 (2022). This paper reports uses of the implantable microdevice in patients.
Li, A. et al. Characterizing advanced breast cancer heterogeneity and treatment resistance through serial biopsies and comprehensive analytics. NPJ Precis. Oncol. 5, 28 (2021). This article presents the SMMART precision oncology program for transformative anticancer treatments based on the entire cancer ecosystem.
Johnson, B. E. et al. An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer. Cell Rep. Med. 3, 100525 (2022). A primary article that describes mechanisms of therapeutic resistance revealed by integrative analysis of cancer genome, signaling, microenvironment organization and ultrastructure from serial biopsies in individual patients.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Tatarova, Z. et al. A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01379-y (2022).
Rights and permissions
About this article
Cite this article
Identifying drug combinations that enhance treatment responses mediated by the tumor microenvironment. Nat Biotechnol 40, 1770–1771 (2022). https://doi.org/10.1038/s41587-022-01380-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41587-022-01380-5