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Identifying drug combinations that enhance treatment responses mediated by the tumor microenvironment

Drug combinations predicted to increase tumor cell death directly and by creating strong antitumor tumor microenvironments were identified by computational analysis of local responses to combinations of anticancer drugs delivered inside a tumor. Such predicted drug combinations were highly effective when administered systemically in mouse models of breast cancer.

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Fig. 1: Spatial analysis of local intratumoral drug response predicts combination treatment efficacy.


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This is a summary of: Tatarova, Z. et al. A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs. Nat. Biotechnol. (2022).

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Identifying drug combinations that enhance treatment responses mediated by the tumor microenvironment. Nat Biotechnol (2022).

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