Our multidisciplinary team used novel perfusion technology to successfully keep an injured liver graft discarded by all other centers alive for several days, allowing proper graft evaluation and repair. The graft was successfully transplanted into a sick patient, who recovered quickly and enjoyed a normal life at one-year follow up.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Nasralla, D. & Coussious, C. C. A randomized trial of normothermic preservation in liver transplantation. Nature 557, 50–56 (2018). This is the first randomized trial involving normothermic machine perfusion before liver transplantation.
Eshmuminov, D. & Becker, D. An integrated perfusion machine preserves injured human livers for 1 week. Nat. Biotechnol. 38, 189–198 (2020). This paper reports for the first time preservation of discarded livers for one week.
Mueller, M. & Hefti, M. L. Long-term normothermic machine preservation of partial livers: first experience with 21 human hemi-livers. Ann. Surg. 274, 836–842 (2021). This paper presents the first experience with partial liver perfusion for one week.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Clavien, P.-A. et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01354-7 (2022)
Rights and permissions
About this article
Cite this article
First liver transplantation using a graft maintained ex vivo for several days. Nat Biotechnol 40, 1578–1579 (2022). https://doi.org/10.1038/s41587-022-01355-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41587-022-01355-6