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Light-sheet microscopy at high resolution

An improved light-sheet microscope images live cells at sub-100-nm axial resolution.

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Fig. 1: Three-dimensional interferometric lattice light-sheet imaging.


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The author is grateful for funding by the National Institutes of Health (R35GM133522) and thanks James Manton for help simulating the 4Pi point spread function used in Fig. 1b,d.

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Correspondence to Reto Fiolka.

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Fiolka, R. Light-sheet microscopy at high resolution. Nat Biotechnol (2021).

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