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Building a high-quality Human Cell Atlas


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Fig. 1: Mission of the Standards and Technology Working Group (STWG).
Fig. 2: Enabling high-quality, cost-effective data generation through systematic benchmarking and decision trees.


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We thank A. K. Shalek for insightful comments on the manuscript. This work has received funding from the Ministerio de Ciencia, Innovación y Universidades of Spain (SAF2017-89109-P; AEI/FEDER, UE). J.W.S. received a research grant for the RIKEN Center for Integrative Medical Sciences from MEXT. This project has been made possible in part by grant number 2018-182827 and HCA-A-1704-01742 from the Chan Zuckerberg Initiative DAF, an advised fund of the Silicon Valley Community Foundation. Work was supported by the Manton Foundation, the Klarman Cell Observatory and HHMI (A.R.). This publication is also supported as part of a project (BCLLATLAS and ESPACE) that has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement No 810287 and 874710). We acknowledge support of the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa and the CERCA Programme / Generalitat de Catalunya. We also acknowledge the support of the Spanish Ministry of Science and Innovation through the Instituto de Salud Carlos III, the Generalitat de Catalunya through Departament de Salut and Departament d’Empresa i Coneixement, and co-financing by the Spanish Ministry of Ministry of Science and Innovation with funds from the European Regional Development Fund (ERDF) corresponding to the 2014–2020 Smart Growth Operating Program.

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Correspondence to Holger Heyn.

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A.R. is a cofounder and equity holder of Celsius Therapeutics, an equity holder in Immunitas and an SAB member of ThermoFisher Scientific, Syros Pharmaceuticals, Asimov and Neogene Therapeutics. A.R. is a co-inventor on patent applications to advances in single-cell genomics, including droplet-based sequencing technologies, as in PCT/US2015/0949178, and methods for expression and analysis, as in PCT/US2016/059233 and PCT/US2016/059239. O.R.R. is a co-inventor on patent applications filed by the Broad Institute for inventions relating to single-cell genomics, such as in PCT/US2018/060860 and US Provisional Application No. 62/745259.

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Rozenblatt-Rosen, O., Shin, J.W., Rood, J.E. et al. Building a high-quality Human Cell Atlas. Nat Biotechnol 39, 149–153 (2021).

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