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How bans on germline editing deprive patients with mitochondrial disease

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References

  1. 1.

    Adashi, E. Y. & Cohen, I. G. Cell 164, 832–835 (2016).

    CAS  Article  Google Scholar 

  2. 2.

    Cohen, I. G. & Adashi, E. Y. Nat. Rev. Genet. 17, 189–190 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Cohen, I. G. & Adashi, E. Y. J. Am. Med. Assoc. 316, 273–274 (2016).

    Article  Google Scholar 

  4. 4.

    Liang, P. et al. Protein Cell 6, 363–372 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    The Hinxton Group. Statement on Genome Editing Technologies and Human Germline Genetic Modification. http://www.hinxtongroup.org/Hinxton2015_Statement.pdf (2015).

  6. 6.

    International Summit on Human Gene Editing. On Human Gene Editing: International Summit Statement http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=12032015a (2015).

  7. 7.

    National Academies of Sciences, Engineering, and Medicine. Human Genome Editing: Science, Ethics, and Governance (National Academies Press, Washington, DC, 2017).

  8. 8.

    Gorman, G. S., Grady, J. P. & Turnbull, D. M. N. Engl. J. Med. 372, 885–887 (2015).

    CAS  Article  Google Scholar 

  9. 9.

    Mitalipov, S., Amato, P., Parry, S. & Falk, M. J. Cell Rep. 7, 935–937 (2014).

    CAS  Article  Google Scholar 

  10. 10.

    Isasi, R., Kleiderman, E. & Knoppers, B. M. Science 351, 337–339 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Collins, F. S. & Gottlieb, S. N. Engl. J. Med. 379, 1393–1395 (2018).

    Article  Google Scholar 

  12. 12.

    Assisted Human Reproduction Act, S.C. 2004. http://laws-lois.justice.gc.ca/PDF/A-13.4.pdf (2018)

  13. 13.

    CNN. Rael defends claims of cloned baby. http://www.cnn.com/2003/ALLPOLITICS/01/03/cf.opinion.rael/ (2003).

  14. 14.

    Nisbet, M. C. Public Opin. Q. 68, 131–154 (2004).

    Article  Google Scholar 

  15. 15.

    Knoppers, B. M. et al. Regen. Med. 2, 3 (2017).

    Article  Google Scholar 

  16. 16.

    Ogbogu, U. et al. Healthc. Policy 13, 10–19 (2018).

    PubMed  PubMed Central  Google Scholar 

  17. 17.

    Knoppers, B.M. et al. Consensus Statement: Gene Editing, Genetic Testing, and Reproductive Medicine in Canada. https://stemcellnetwork.ca//wp-content/uploads/2018/02/Consensus-Statement_.pdf (2018).

  18. 18.

    H.R.2880 – 104th Congress (1995–1996): Balanced Budget Downpayment Act, I. https://www.congress.gov/bill/104th-congress/house-bill/2880/text (1996).

  19. 19.

    Spivak, R. A., Cohen, I. G. & Adashi, E. Y. J. Law Health 30, 20–54 (2017).

    PubMed  Google Scholar 

  20. 20.

    Adashi, E. Y. & Cohen, I. G. Trends Mol. Med. 24, 449–457 (2018).

    CAS  Article  Google Scholar 

  21. 21.

    Cohen, I. G. Stanford Law Rev. 60, 1135–1196 (2007).

    Google Scholar 

  22. 22.

    National Academies of Sciences, Engineering, and Medicine. Mitochondrial Replacement Technique: Ethical, Social, and Policy Considerations (National Academies Press, Washington, DC, 2016). .

  23. 23.

    Luo, S. et al. Proc. Natl Acad. Sci. USA 115, 13039–13044 (2018).

    CAS  Article  Google Scholar 

  24. 24.

    United Nations. Universal Declaration of Human Rights. http://www.un.org/en/universal-declaration-human-rights/ (2015).

  25. 25.

    Commission de l’Éthique en Science et en Technologie. Genetically Modified Babies: Ethical Issues Raised by the Genetic Modification of Germ Cells and Embryos: Summary and Recommendations. http://www.ethique.gouv.qc.ca/en/assets/documents/modification%20genetique/CEST_modif_gene_resume_AN_ACC.pdf (2019).

  26. 26.

    United Nations. International Covenant on Economic, Social and Cultural Rights. https://treaties.un.org/Pages/ViewDetails.aspx?src=TREATY&mtdsg_no=IV-3&chapter=4&clang=_en (2018).

  27. 27.

    Cohen, I.G. Patients with Passports: Medical Tourism, Law, and Ethics (Oxford Univ. Press, 2014).

  28. 28.

    Cohen, I. G. Indiana J. Glob. Leg. Stud. 25, 439–462 (2018).

    Article  Google Scholar 

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Correspondence to I. Glenn Cohen.

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Cohen, I.G., Adashi, E.Y. & Ravitsky, V. How bans on germline editing deprive patients with mitochondrial disease. Nat Biotechnol 37, 589–592 (2019). https://doi.org/10.1038/s41587-019-0145-8

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