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Evolution of CAR T-cell immunotherapy in terms of patenting activity

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An analysis of published patent applications in chimeric antigen receptor (CAR) T-cell immunotherapy allows insight into the development of this emerging technology.

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Fig. 1
Fig. 2: Geographical analysis of CAR T-cell patenting activity.
Fig. 3
Fig. 4: Patenting evolution of the top five CAR T-cell applicants.
Fig. 5: Network node map of CAR T-cell applicants.
Fig. 6: CAR T-cell patent value analysis.

Change history

  • 09 April 2019

    In the version of this article initially published online, the abstract read “dedvelopment” instead of “development” as a result of a publisher error. The error has been corrected in the print, PDF and HTML versions of this article.


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This article is based on a study that was commissioned by the European Patent Office with the aim of demonstrating to readers outside the disciplines of patent analysis and CAR T-cell immunotherapy how patent information can be used to gain insight and competitive advantages about a specific technological field. The authors thank F. Aslund, P. Bumb and D. Manu from the European Patent Office for their support in the classification identification process and assistance for fine-tuning the search strategy. The opinions expressed in this article are those of the authors and not necessarily those of their employers.

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Correspondence to Nigel S. Clarke.

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Jürgens, B., Clarke, N.S. Evolution of CAR T-cell immunotherapy in terms of patenting activity. Nat Biotechnol 37, 370–375 (2019).

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