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Facing up to the global challenges of ageing

Naturevolume 561pages4556 (2018) | Download Citation


Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals and drugs can all improve late-life health in animals. Application to humans will require better biomarkers of disease risk and responses to interventions, closer alignment of work in animals and humans, and increased use of electronic health records, biobank resources and cohort studies.

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We thank N. van den Berg for help with the preparation of Fig. 1 and N. Chaturvedi and B. J. Zwaan for their critical reading of the manuscript. L.P. acknowledges support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (no. 741989) and a Wellcome Trust Strategic Award. J.D. acknowledges support from the Alexander von Humboldt Foundation. We apologize to the authors of many relevant studies for not citing their work owing to space limitations.

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Nature thanks V. D. Longo and J. Vijg for their contribution to the peer review of this work.

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  1. Max Planck Institute for Biology of Ageing, Cologne, Germany

    • Linda Partridge
    • , Joris Deelen
    •  & P. Eline Slagboom
  2. Institute of Healthy Ageing, and Department of Genetics, Evolution and Environment, UCL, London, UK

    • Linda Partridge
  3. Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands

    • Joris Deelen
    •  & P. Eline Slagboom


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All authors contributed to the design and writing of the Review.

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The authors declare no competing interests.

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Correspondence to Linda Partridge or P. Eline Slagboom.

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