Retraction to: Nature, published online 16 December 2015; corrected 20 January 2016.

In follow-up experiments to this Article, we have been unable to replicate key aspects of the original results. Most importantly, an RNA-dependent physical association of RORγt and DDX5 cannot be reproduced and is not substantiated upon further analysis of the original data. The authors therefore wish to retract the Article. We deeply regret this error and apologize to our scientific colleagues. Dan R. Littman, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang and Oreste Acuto agree to the Retraction. Wendy Huang declined to sign the Retraction letter.

Author information


  1. The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York, 10016, USA

    • Wendy Huang
    • , Samuel J. Gavzy
    • , Lin Wu
    • , Sangwon V. Kim
    • , Jason A. Hall
    • , Emily R. Miraldi
    • , Charles P. Ng
    • , Nina R. Montoya
    • , Natalia G. Herrera
    •  & Dan R. Littman
  2. Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK

    • Benjamin Thomas
    •  & Oreste Acuto
  3. Center for Personal Dynamic Regulomes, Stanford University, Stanford, California, 94305, USA

    • Ryan A. Flynn
    •  & Howard Y. Chang
  4. Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, 10003, USA

    • Emily R. Miraldi
    •  & Richard Bonneau
  5. Courant Institute of Mathematical Sciences, Computer Science Department, New York University, New York, New York, 10012, USA

    • Emily R. Miraldi
    •  & Richard Bonneau
  6. Simons Center for Data Analysis, Simons Foundation, New York, New York, 10010, USA

    • Emily R. Miraldi
    •  & Richard Bonneau
  7. Isis Pharmaceuticals, Carlsbad, California, 92010, USA

    • Frank Rigo
  8. HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, 35806, USA

    • Sarah Meadows
    •  & Richard M. Myers
  9. Instituto Gulbenkian de Ciencia, Oeiras, 2780-156, Portugal

    • Ana I. Domingos
  10. Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, 32827, USA

    • Fraydoon Rastinejad
  11. Division of Cancer Research, University of Dundee, Dundee, DD1 9SY, UK

    • Frances V. Fuller-Pace
  12. Howard Hughes Medical Institute, New York University School of Medicine, New York, New York, 10016, USA

    • Dan R. Littman


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Correspondence to Dan R. Littman.

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