In the SELENIB trial, selenium and vitamin E were compared with placebo as chemoprevention for non-muscle-invasive bladder cancer (NMIBC). No difference versus placebo was observed in recurrence-free interval (RFI) with selenium, but vitamin E was associated with worse RFI. Selenium and vitamin E cannot be recommended in chemoprevention for NMIBC. Furthermore, patients with NMIBC taking supplemental vitamin E should be made aware of its potential association with worse RFI.
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Trecarten, S.J., Svatek, R.S. Supplementary selenium and vitamin E in non-muscle-invasive bladder cancer. Nat Rev Urol (2024). https://doi.org/10.1038/s41585-024-00859-x
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DOI: https://doi.org/10.1038/s41585-024-00859-x
