Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Inheritance in overactive bladder syndrome

Despite the high prevalence of overactive bladder (OAB) syndrome, its pathophysiology remains poorly understood. Twin studies offer a unique opportunity for studying the genetics of this disorder, but trials are limited by heterogeneous patient populations. Improved understanding of genetic factors in OAB will be vital to developing targeted management.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Cartwright, R. et al. Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women. Am. J. Obstet. Gynecol. 212, 199.e1–199.e24 (2015).

    Article  CAS  Google Scholar 

  2. Peyronnet, B. et al. A comprehensive review of overactive bladder pathophysiology: on the way to tailored treatment. Eur. Urol. 75, 988–1000 (2019).

    Article  Google Scholar 

  3. Tsiapakidou, S., Apostolidis, A., Pantazis, K., Grimbizis, G. F. & Mikos, T. The use of urinary biomarkers in the diagnosis of overactive bladder in female patients. A systematic review and meta-analysis. Int. Urogynecol. J. 32, 3143–3155 (2021).

    Article  Google Scholar 

  4. Li, K. et al. Interplay between bladder microbiota and overactive bladder symptom severity: a cross-sectional study. BMC Urol. 22, 39 (2022).

    Article  CAS  Google Scholar 

  5. Post, W. M. et al. Genetic variants and expression changes in urgency urinary incontinence: a systematic review. Neurourol. Urodyn. 39, 2089–2110 (2020).

    Article  Google Scholar 

  6. Wennberg, A.-L. et al. Genetic influences are important for most but not all lower urinary tract symptoms: a population-based survey in a cohort of adult Swedish twins. Eur. Urol. 59, 1032–1038 (2011).

    Article  Google Scholar 

  7. Rohr, G., Kragstrup, J., Gaist, D. & Christensen, K. Genetic and environmental influences on urinary incontinence: a Danish population-based twin study of middle-aged and elderly women. Acta Obstet. Gynecol. Scand. 83, 978–982 (2004).

    Article  Google Scholar 

  8. Afari, N. et al. Heritability of lower urinary tract symptoms in men: a twin study. J. Urol. 196, 1486–1492 (2016).

    Article  Google Scholar 

  9. Gasperi, M. et al. Genetic and environmental influences on urinary conditions in men: a classical twin study. Urology 129, 54–59 (2019).

    Article  Google Scholar 

  10. Rohrmann, S. et al. Concordance rates and modifiable risk factors for lower urinary tract symptoms in twins. Epidemiology 17, 419–427 (2006).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Arun Sahai.

Ethics declarations

Competing interests

S.M. declares an educational grant by Medtronic and speaker fees by Medtronic. A.S. declares educational grants by Medtronic, Boston scientific and Saluda Medical and speaker fees by Ferring, Allergan, Medtronic and Boston Scientific. N.R. declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Raison, N., Malde, S. & Sahai, A. Inheritance in overactive bladder syndrome. Nat Rev Urol 20, 61–62 (2023). https://doi.org/10.1038/s41585-022-00667-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41585-022-00667-1

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing