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Inheritance in overactive bladder syndrome

Despite the high prevalence of overactive bladder (OAB) syndrome, its pathophysiology remains poorly understood. Twin studies offer a unique opportunity for studying the genetics of this disorder, but trials are limited by heterogeneous patient populations. Improved understanding of genetic factors in OAB will be vital to developing targeted management.

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  1. Cartwright, R. et al. Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women. Am. J. Obstet. Gynecol. 212, 199.e1–199.e24 (2015).

    Article  CAS  Google Scholar 

  2. Peyronnet, B. et al. A comprehensive review of overactive bladder pathophysiology: on the way to tailored treatment. Eur. Urol. 75, 988–1000 (2019).

    Article  Google Scholar 

  3. Tsiapakidou, S., Apostolidis, A., Pantazis, K., Grimbizis, G. F. & Mikos, T. The use of urinary biomarkers in the diagnosis of overactive bladder in female patients. A systematic review and meta-analysis. Int. Urogynecol. J. 32, 3143–3155 (2021).

    Article  Google Scholar 

  4. Li, K. et al. Interplay between bladder microbiota and overactive bladder symptom severity: a cross-sectional study. BMC Urol. 22, 39 (2022).

    Article  CAS  Google Scholar 

  5. Post, W. M. et al. Genetic variants and expression changes in urgency urinary incontinence: a systematic review. Neurourol. Urodyn. 39, 2089–2110 (2020).

    Article  Google Scholar 

  6. Wennberg, A.-L. et al. Genetic influences are important for most but not all lower urinary tract symptoms: a population-based survey in a cohort of adult Swedish twins. Eur. Urol. 59, 1032–1038 (2011).

    Article  Google Scholar 

  7. Rohr, G., Kragstrup, J., Gaist, D. & Christensen, K. Genetic and environmental influences on urinary incontinence: a Danish population-based twin study of middle-aged and elderly women. Acta Obstet. Gynecol. Scand. 83, 978–982 (2004).

    Article  Google Scholar 

  8. Afari, N. et al. Heritability of lower urinary tract symptoms in men: a twin study. J. Urol. 196, 1486–1492 (2016).

    Article  Google Scholar 

  9. Gasperi, M. et al. Genetic and environmental influences on urinary conditions in men: a classical twin study. Urology 129, 54–59 (2019).

    Article  Google Scholar 

  10. Rohrmann, S. et al. Concordance rates and modifiable risk factors for lower urinary tract symptoms in twins. Epidemiology 17, 419–427 (2006).

    Article  Google Scholar 

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Correspondence to Arun Sahai.

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Competing interests

S.M. declares an educational grant by Medtronic and speaker fees by Medtronic. A.S. declares educational grants by Medtronic, Boston scientific and Saluda Medical and speaker fees by Ferring, Allergan, Medtronic and Boston Scientific. N.R. declares no competing interests.

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Raison, N., Malde, S. & Sahai, A. Inheritance in overactive bladder syndrome. Nat Rev Urol 20, 61–62 (2023).

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