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The unclear role of PET–CT in localized radiorecurrent prostate cancer

Prostate cancer recurrence is common after radical radiotherapy and the increasing use of novel, minimally invasive salvage treatments means that accurate detection and localization of radiorecurrent disease is vital in treatment planning and delivery. PET–CT is increasingly used to detect metastatic disease; however, data regarding its value for identifying and accurately characterizing intraprostatic recurrence need improvement.

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  1. National Prostate Cancer Audit. NPCA Annual Report 2020 (National Prostate Cancer Audit, 2021).

  2. Zumsteg, Z. S. et al. The natural history and predictors of outcome following biochemical relapse in the dose escalation era for prostate cancer patients undergoing definitive external beam radiotherapy. Eur. Urol. 67, 1009–1016 (2015).

    Article  Google Scholar 

  3. Gaur, S. & Turkbey, B. Prostate MR imaging for posttreatment evaluation and recurrence. Radiol. Clin. North Am. 56, 263–275 (2018).

    Article  Google Scholar 

  4. Shah, T. T. et al. Magnetic resonance imaging and targeted biopsies compared to transperineal mapping biopsies before focal ablation in localised and metastatic recurrent prostate cancer after radiotherapy. Eur. Urol. 81, 598–605 (2022).

    Article  Google Scholar 

  5. Crocerossa, F. et al. Detection rate of prostate specific membrane antigen tracers for positron emission tomography/computerized tomography in prostate cancer biochemical recurrence: a systematic review and network meta-analysis. J. Urol. 205, 356–369 (2021).

    Article  Google Scholar 

  6. Valle, L. F. et al. A systematic review and meta-analysis of local salvage therapies after radiotherapy for prostate cancer (MASTER). Eur. Urol. 80, 280–292 (2021).

    Article  Google Scholar 

  7. Kanthabalan, A. et al. Intraprostatic cancer recurrence following radical radiotherapy on transperineal template mapping biopsy: implications for focal ablative salvage therapy. J. Urol. 204, 950–955 (2020).

    Article  CAS  Google Scholar 

  8. Golbari, N. M. & Katz, A. E. Salvage therapy options for local prostate cancer recurrence after primary radiotherapy: a literature review. Curr. Urol. Rep. 18, 63 (2017).

    Article  Google Scholar 

  9. Fendler, W. P. et al. False positive PSMA PET for tumor remnants in the irradiated prostate and other interpretation pitfalls in a prospective multi-center trial. Eur. J. Nucl. Med. Mol. Imaging 48, 501–508 (2021).

    Article  CAS  Google Scholar 

  10. Perera, M. et al. Gallium-68 prostate-specific membrane antigen positron emission tomography in advanced prostate cancer-updated diagnostic utility, sensitivity, specificity, and distribution of prostate-specific membrane antigen-avid lesions: a systematic review and meta-analysis. Eur. Urol. 77, 403–417 (2020).

    Article  Google Scholar 

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Correspondence to Taimur T. Shah.

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Competing interests

H.U.A. receives core funding from the UK National Institute of Health Research (NIHR) Imperial Biomedical Research Centre, the Wellcome Trust, the UK NIHR, the UK Medical Research Council, Cancer Research UK, Prostate Cancer UK, The Urology Foundation, the BMA Foundation, Imperial Healthcare Charity, Sonacare, Trod Medical and Sophiris Biocorp; has received a travel allowance from Sonacare; was a paid consultant for Sophiris Biocorp and Sonacare; and is a proctor for Rezūm treatment and cryotherapy for Boston Scientific. The other authors declare no competing interests.

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Light, A., Ahmed, H.U. & Shah, T.T. The unclear role of PET–CT in localized radiorecurrent prostate cancer. Nat Rev Urol 19, 573–574 (2022).

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