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Does semen analysis testing reveal disparities?

Evidence for the existence of racial disparities in semen parameters is increasing, exemplified by a recent study in men from white, Black and Asian populations. However, reference standards for semen parameters might not account for these disparities.

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  1. Kasman, A. M., Del Giudice, F. & Eisenberg, M. L. New insights to guide patient care: the bidirectional relationship between male infertility and male health. Fertil. Steril. 113, 469–477 (2020).

    Article  CAS  Google Scholar 

  2. Del Giudice, F. et al. Increased mortality among men diagnosed with impaired fertility: analysis of US claims data. Urology 147, 143–149 (2021).

    Article  Google Scholar 

  3. Del Giudice, F. et al. Association between male infertility and male-specific malignancies: systematic review and meta-analysis of population-based retrospective cohort studies. Fertil. Steril. 114, 984–996 (2020).

    Article  Google Scholar 

  4. Walker, Z. et al. Investigation of racial disparities in semen parameters among white, black, and Asian men. Andrology (2021).

    Article  PubMed  Google Scholar 

  5. Khandwala, Y. S. et al. Racial variation in semen quality at fertility evaluation. Urology 106, 96–102 (2017).

    Article  Google Scholar 

  6. Gao, J. et al. Reference values of semen parameters for healthy Chinese men. Urol. Int. 81, 256–262 (2008).

    Article  Google Scholar 

  7. Iwamoto, T. Semen quality of 324 fertile Japanese men. Hum. Reprod. 21, 760–765 (2006).

    Article  CAS  Google Scholar 

  8. Redmon, J. B. et al. Semen parameters in fertile US men: the Study for Future Families. Andrology 1, 806–814 (2013).

    Article  CAS  Google Scholar 

  9. Glazer, C. H. et al. Racial and sociodemographic differences of semen parameters among US men undergoing a semen analysis. Urology 123, 126–132 (2019).

    Article  Google Scholar 

  10. Vilson, F. L. et al. Removing race from eGFR calculations: implications for urologic care. Urology (2021).

    Article  PubMed  Google Scholar 

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Correspondence to Michael L. Eisenberg.

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Del Giudice, F., Eisenberg, M.L. Does semen analysis testing reveal disparities?. Nat Rev Urol 18, 515 (2021).

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