Bladder cancer outcomes differ between men and women. Elucidating this sexual dimorphism, genomic analyses found differing molecular subtype distributions and androgen response activities in muscle-invasive bladder cancer in men and women. Together with knowledge of cancer driver genes, biomarkers and clinical characteristics, these findings will hopefully lead to sex-based personalized research and management of bladder cancer.
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Najari, B. B. et al. Sex disparities in cancer mortality: the risks of being a man in the United States. J. Urol. 189, 1470–1474 (2013).
Mori, K. et al. Differential effect of sex on outcomes after radical surgery for upper tract and bladder urothelial carcinoma: a systematic review and meta-analysis. J. Urol. https://doi.org/10.1097/JU.0000000000000788 (2020).
Dobruch, J. et al. Gender and bladder cancer: a collaborative review of etiology, biology, and outcomes. Eur. Urol. 69, 300–310 (2016).
Yuan, Y. et al. Comprehensive characterization of molecular differences in cancer between male and female patients. Cancer Cell 29, 711–722 (2016).
Kamoun, A. et al. A consensus molecular classification of muscle-invasive bladder cancer. Eur. Urol. 77, 420–433 (2019).
de Jong, J. J. et al. Distribution of molecular subtypes in muscle-invasive bladder cancer is driven by sex-specific differences. Eur. Urol. Oncol. https://doi.org/10.1016/j.euo.2020.02.010 (2020).
Trilla-Fuertes, L. et al. Biological molecular layer classification of muscle-invasive bladder cancer opens new treatment opportunities. BMC Cancer 19, 636 (2019).
Jahrreiss, V., Pradere, B., Laukhtina, E., Mori, K. & Shariat, S. F. Catalog of exogenous risk factors for bladder carcinogenesis. Curr. Opin. Urol. 30, 449–456 (2020).
Krimphove, M. J. et al. Sex-specific differences in the quality of treatment of muscle-invasive bladder cancer do not explain the overall survival discrepancy. Eur. Urol. Focus https://doi.org/10.1016/j.euf.2019.06.001 (2019).
Lucca, I., Klatte, T., Fajkovic, H., de Martino, M. & Shariat, S. F. Gender differences in incidence and outcomes of urothelial and kidney cancer. Nat. Rev. Urol. 12, 653 (2015).
The authors declare no competing interests.
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Pradere, B., Shariat, S.F. Exploring the molecular basis of sexual dimorphism in bladder cancer. Nat Rev Urol 17, 487–488 (2020). https://doi.org/10.1038/s41585-020-0339-3