Bladder cancer outcomes differ between men and women. Elucidating this sexual dimorphism, genomic analyses found differing molecular subtype distributions and androgen response activities in muscle-invasive bladder cancer in men and women. Together with knowledge of cancer driver genes, biomarkers and clinical characteristics, these findings will hopefully lead to sex-based personalized research and management of bladder cancer.
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Pradere, B., Shariat, S.F. Exploring the molecular basis of sexual dimorphism in bladder cancer. Nat Rev Urol 17, 487–488 (2020). https://doi.org/10.1038/s41585-020-0339-3
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DOI: https://doi.org/10.1038/s41585-020-0339-3