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Does MRI-guided TULSA provide a targeted approach to ablation?

MRI-guided transurethral ultrasound ablation is an exciting, minimally invasive technology with the potential to provide targeted ablation of prostate cancer tissue. At 3 years, functional outcomes remain good with 76% remaining free from salvage treatment. Future studies using a focal approach may provide evidence for widespread uptake of this technology.

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References

  1. Resnick, M. J. et al. Long-term functional outcomes after treatment for localized prostate cancer. N. Engl. J. Med. 368, 436–445 (2013).

    Article  CAS  Google Scholar 

  2. Ahmed, H. U. The index lesion and the origin of prostate cancer. N. Engl. J. Med. 361, 1704–1706 (2009).

    Article  CAS  Google Scholar 

  3. Chin, J. L. et al. Magnetic resonance imaging-guided transurethral ultrasound ablation of prostate tissue in patients with localized prostate cancer: a prospective phase 1 clinical trial. Eur. Urol. 70, 447–455 (2016).

    Article  Google Scholar 

  4. Nair, S. M. et al. Magnetic resonance imaging-guided transurethral ultrasound ablation in patients with localised prostate cancer: 3-year outcomes of a prospective phase I study. BJU Int. https://doi.org/10.1111/bju.15268 (2020).

    Article  PubMed  Google Scholar 

  5. Crouzet, S. et al. Whole-gland ablation of localized prostate cancer with high-intensity focused ultrasound: oncologic outcomes and morbidity in 1002 patients. Eur. Urol. 65, 907–914 (2014).

    Article  Google Scholar 

  6. Valerio, M. et al. New and established technology in focal ablation of the prostate: a systematic review. Eur. Urol. 71, 17–34 (2017).

    Article  Google Scholar 

  7. Klotz, L. et al. MRI-guided transurethral ultrasound ablation of prostate cancer. J. Urol. https://doi.org/10.1097/JU.0000000000001362 (2020).

    Article  PubMed  Google Scholar 

  8. Shoji, S. et al. Prostate swelling and shift during high intensity focused ultrasound: implication for targeted focal therapy. J. Urol. 190, 1224–1232 (2013).

    Article  Google Scholar 

  9. US National Library of Medicine. ClinicialTrials.gov https://clinicaltrials.gov/ct2/show/NCT03814252 (2020).

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Correspondence to Thomas J. Polascik.

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Arcot, R., Polascik, T.J. Does MRI-guided TULSA provide a targeted approach to ablation?. Nat Rev Urol 18, 5–6 (2021). https://doi.org/10.1038/s41585-020-00403-7

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