Plastics have an integral role in our daily lives but at a considerable cost to the environment and, as we are now learning, to human health. Increased plastic exposure has been linked to compromised endocrine function, reproductive health and semen quality and, potentially, urological cancers. However, the long-term consequences of plastic exposure remain to be seen.
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References
Tsai, C.-F. et al. Curcumin suppresses phthalate-induced metastasis and the proportion of cancer stem cell (CSC)-like cells via the inhibition of AhR/ERK/SK1 signaling in hepatocellular carcinoma. J. Agric. Food Chem. 63, 10388–10398 (2015).
Seachrist, D. D. et al. A review of the carcinogenic potential of bisphenol A. Reprod. Toxicol. 59, 167–182 (2016).
Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A. & Needham, L. L. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004. Environ. Health Perspect. 116, 39–44 (2008).
Ramos, J. G. et al. Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate. Biol. Reprod. 65, 1271–1277 (2001).
Wetherill, Y. B. et al. Bisphenol A facilitates bypass of androgen ablation therapy in prostate cancer. Mol. Cancer Ther. 5, 3181–3190 (2006).
Derouiche, S. et al. Bisphenol A stimulates human prostate cancer cell migration via remodelling of calcium signalling. Springerplus 2, 54 (2013).
Tarapore, P. et al. Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro. PLoS ONE 9, e90332 (2014).
Li, P., Chen, J. & Miyamoto, H. Androgen receptor signaling in bladder cancer. Cancers 9, 20 (2017).
Shiota, M. et al. Suppressed recurrent bladder cancer after androgen suppression with androgen deprivation therapy or 5α-reductase inhibitor. J. Urol. 197, 308–313 (2017).
Kobroob, A., Peerapanyasut, W., Chattipakorn, N. & Wongmekiat, O. Damaging effects of bisphenol A on the kidney and the protection by melatonin: emerging evidences from in vivo and in vitro studies. Oxid. Med. Cell. Longev. 2018, 3082438 (2018).
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Patel, S.H., Metcalf, M., Bivalacqua, T.J. et al. Plastic exposure and urological malignancies — an emerging field. Nat Rev Urol 17, 653–654 (2020). https://doi.org/10.1038/s41585-020-00385-6
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DOI: https://doi.org/10.1038/s41585-020-00385-6
